Calculator Inputs
Built-in factors are illustrative starting points only. You can overwrite any factor, target intensity, rounding rule, or alert threshold.
Example Data Table
Illustrative example only. Replace these values with your own assumptions.
| Current Drug | Current Dose | Current Factor | Target Drug | Target Factor | Switch Days | Target Start | Equivalent Target Dose |
|---|---|---|---|---|---|---|---|
| Olanzapine (oral) | 10 mg/day | 20.00 | Risperidone (oral) | 50.00 | 14 | Day 1 | 4.00 mg/day |
| Quetiapine (oral) | 300 mg/day | 1.33 | Aripiprazole (oral) | 13.33 | 21 | Day 4 | 29.93 mg/day |
| Haloperidol (oral) | 5 mg/day | 100.00 | Olanzapine (oral) | 20.00 | 10 | Day 1 | 25.00 mg/day |
Formula Used
Baseline CPZ-eq = Current Daily Dose × Current Drug Factor
Equivalent Target Dose = (Baseline CPZ-eq ÷ Target Drug Factor) × (Target Intensity % ÷ 100)
The calculator applies a progress curve each day. Source dose falls according to the chosen taper profile, while target dose rises after the selected start day using the chosen titration profile.
Combined CPZ-eq = (Source Dose × Source Factor) + (Target Dose × Target Factor)
This approach lets you compare daily overlap exposure against the starting baseline, flag high combined exposure days, and see how rounding changes the final schedule.
How To Use This Calculator
- Choose the current and target drugs from the preset lists, or keep either entry custom.
- Enter the current daily dose in mg/day.
- Review or overwrite both equivalence factors.
- Set the switch duration and choose the day when the target drug starts.
- Leave target intensity at 100% for a simple equivalent estimate, or change it if your model intentionally differs.
- Select taper and titration profiles to shape early or late dose changes.
- Set a rounding increment that matches your tablet or dispensing assumptions.
- Submit the form to view summary cards, a full schedule table, and a Plotly chart.
- Download the schedule as CSV or PDF for documentation or review.
Frequently Asked Questions
1) What does this calculator estimate?
It estimates an editable cross titration schedule using user-supplied dose-equivalence assumptions. It shows daily source dose, target dose, combined exposure, warnings, and a chart for review.
2) Are the preset factors exact?
No. They are illustrative defaults only. Different references, patient factors, formulations, and clinical goals can produce different equivalent-dose assumptions, so the fields remain fully editable.
3) Can I use this for depot or injectable switches?
This one-file version is best used for oral daily schedules. Depot conversions often need formulation-specific intervals, loading rules, and route-specific guidance that are outside this simple model.
4) Why can combined exposure rise during overlap?
During overlap, the source dose may still contribute substantial exposure while the target dose is already rising. The combined CPZ-equivalent line helps you spot those potentially higher-burden days.
5) What rounding increment should I choose?
Use an increment that matches how you intend to express doses, such as 0.5 mg, 1 mg, 2.5 mg, or 25 mg. Different rounding rules can materially change the schedule.
6) What does target intensity mean?
Target intensity scales the final target dose relative to the simple equivalent estimate. At 100%, the model aims for a basic equivalent match. Higher or lower values intentionally move away from that match.
7) Why export the result to CSV or PDF?
Exports make it easier to review the schedule offline, share a planning worksheet, archive assumptions, and compare multiple models with different factors or overlap profiles.
8) Is this a clinical instruction?
No. It is an educational calculator template. It does not replace individualized prescribing review, formulation-specific guidance, adverse-effect monitoring, or specialist judgment.